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The antinociceptive impact of DSIP was negated by the opioid antagonist naloxone and was not observed in morphine-tolerant mice, suggesting that DSIP acts at the supraspinal level, possibly influencing opioid receptors [11]

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For the myotendinous junction, as a combination point of anatomical and structural particularities (largely reviewed in [124,125]) such a new therapy possibility might be particularly important given the still unresolved problem of being the weakest element in the muscle–tendon unit, (and bone–tendon junctions as extremely specialized tissues in general)