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Sustained dysregulation of iron and glutathione homeostasis induces chronoferroptosis, a persistent ferroptotic adaptation in neuronal cells | Cell Death Discovery

During unusual circumstances, such as the COVID-19 pandemic, the approach to managing chronic conditions like pernicious anaemia, which requires regular B12 injections, had to be adapted, potentially influencing the perception of efficacy and safety of the treatment among patients

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Higher expression of HMOX1 in the cellular medium accelerated the heme metabolism, which increased the level of intracellular iron and enhanced the ferritin production