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Some practitioners theorize that local administration to abdominal fat may enhance regional lipolytic effects, though this has not been conclusively proven

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Rilotumumab has also been evaluated in a phase II trial aiming to study its safety and efficacy in combination with bevacizumab (Avastin®, Genentech, South San Francisco, California, USA) for the treatment of recurrent malignant glioma, showing no significant improvement and low tolerability [95]