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Concurrent use with anticoagulants, NSAIDs, or other angiogenic agents should be discussed with a clinician before proceeding

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First, the sulfonation reaction saturates and that allows more NAPQI to accumulate ( [7,24]) and second, the increased amount of NAPQI exhausts the liver stores of reduced glutathione (GSH) [6] as well as the liver’s capacity to synthesize new GSH