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Oral administration of HGSD (100 mg/kg) significantly improved glucose and lipid metabolism in diabetic rats compared with pure BBR (100 mg/kg), BBR tablets (100 mg/kg), or metformin (300 mg/kg),this related to the inhibition of iPLA2/p38 MAPK pathway to decrease β-cell apoptosis (Zhaojie et al., 2014)