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More recently, single-cell RNA sequencing has transformed the resolution at which adipocyte heterogeneity can be studied, revealing discrete CAA clusters enriched in ECM remodeling and cytokine signatures

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Beyond its immune-related roles, tryptophan is involved in hepatic function, specifically in the synthesis of niacin (vitamin B3), which is essential for energy metabolism and DNA synthesis (Bouma et al., Similar to GWS and ME/CFS, disruptions in purine metabolism are suspected to play a role in the pathophysiology of FM