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Curcumin appears to modulate novel gut–liver endocrine axes by suppressing GIP release from hypoxic intestinal tissue, thereby attenuating adipose inflammation, and by coordinating hepatocyte cell death pathways—promoting autophagy (↑BECN1, ↓p62) while inhibiting pyroptosis (↓Gasdermin D, ↓caspase-1, ↓TNF-α, ↓IL-1β)