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We also found metabolic pathways that were uniformly altered irrespective of location such as the fatty acid degradation pathway (Fig 1C yellow nodes and Table C S1 File)

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27 Also, fasting (by shunting acetaminophen metabolism away from glucuronidation or by depletion of intracellular GSH) and chronic ethanol use (via intracellular GSH depletion) can increase susceptibility to acetaminophen hepatotoxicity