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Notably, upregulation of serpinA3N was found in AD model mice (Han et al., 2024)

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Moreover, in cases where the biosynthesis and activity of most selenoproteins reach saturation due to an excessive selenium diet [72], some low-molecular-weight reactive selenium metabolites or intermediates such as selenosugars may exhibit antagonistic effects with TXNRDs and interfere with the related antioxidant system [73]

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