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[ Also, obesity is accompanied by macrophage adipose tissue infiltration, and macrophage-secreted inflammatory cytokines, such as MCP-1, affect the metabolism of adipocytes

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Molecular docking experiments had found that pseudo-Berberine (IMBY 53) had a lower affinity for P-gp, enhancing its blood sugar-lowering effect by prolonging its retention time in hepatocytes and muscle cells (Shan et al., 2013)