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→ Management: Limit use to 4–6 week cycles with at least equal time off → Consider using GH peptides like GHRP‑2 or CJC‑1295 during off cycles to maintain baseline IGF-1 activity → Risk of Unwanted Growth (Organs, Gut, Tumors) Long-term, excessive IGF‑1 can theoretically increase the risk of visceral organ growth , insulin resistance , or even tumor promotion , due to its role in cell proliferation

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Human clinical trial data is limited