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Early use of N-acetylcysteine with nitrate therapy in patients undergoing primary percutaneous coronary intervention for ST-segment-elevation myocardial infarction reduces myocardial infarct size (the NACIAM Trial [N-acetylcysteine in Acute Myocardial Infarction])

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The mechanisms involve MAPK/ERK pathway activation, which upregulates collagen gene expression and promotes fibroblast proliferation