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By modulating nuclear factor-kappa B (NF-kB)—a primary cellular switch that turns on inflammatory genes—adequate glutathione levels can help prevent the immune system from overreacting, keeping baseline intestinal inflammation in check

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Although folic acid may indirectly modulate redox balance by increasing glutathione (GSH) levels, enhancing total antioxidant capacity (TAC), and reducing malondialdehyde (MDA), randomized clinical trials have shown that high-dose folic acid supplementation does not reduce the incidence of PE