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Measurement of F 2 -IsoPs is commonly performed in urine due to their chemical stability brought about by a lack of artificial auto-oxidation (Reference Cracowski, Durand and Bessard68)

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Thus, we can assume that pathways additional to those involved in angiogenesis (Vukojevic et al., 2018) are associated with the increased expression, internalization of VEGFR2, and the activation of the VEGFR2-Akt-eNOS signaling pathway (Hsieh et al., 2017)