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Recombinant growth factors known to promote skin and bone wound healing, such as platelet-derived growth factors (13, 44, 65, 106, 112, 136), insulin like growth factors (42, 44, 56, 84), fibroblast growth factors) (47, 98, 145, 151, 152) and bone morphogenetic proteins (40, 57, 147, 162, 163) have been used in pre-clinical and clinical trials for the treatment of large periodontal or infra-bony defects, as well as around dental implants (34, 66, 106)