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Well said. While Bryan Johnson's experience is just a single case (an n=1) and doesn't establish causation the way a randomized controlled trial can, it highlights an important issue: we simply don't

After homocysteine injection for two weeks the rats showed elevated Aβ42 level in the retina as well as abundant intracellular Aβ accumulation in the ganglion cell layer

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Research has found that patients with hyperthyroidism may suffer from frontal cortex and limbic system metabolic disorders, as well as dopamine dysfunction