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These changes were found to be caused by endothelial cell dysfunction rather than a smooth muscle cell defect, as stimulation of mesenteric vessels with the NO donor sodium nitroprusside yielded the same vasodilatory response in CBS +/− and wildtype vessels

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To discriminate the effectiveness of drug candidates, for both the glutathione and senescence assays, we defined a signal range bounded by the values of the assay result for 0 Gy unirradiated and 15 Gy irradiated controls