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IGF-1LR3

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In AP models, excessive activation of DRP1 and/or downregulation of MFN1/2 and OPA1 has been associated with pathological mitochondrial fragmentation, loss of ΔΨm, decreased ATP production, and accumulation of dysfunctional mitochondria ( Under pathophysiological conditions, particularly during necroptosis and other regulated forms of cell death, cytoskeletal remodeling and mitochondrial dynamics become tightly intertwined