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GHRH(1-29) given twice daily reversed the age-related decline in both GH and IGF-1 in men aged 60 to 78 (Corpas et al., J Clin Endocrinol Metab, 1992, PMID 1379256)

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demonstrated that Gln deprivation reduces the levels of key TCA cycle intermediates, thereby inhibiting tumor cell proliferation [51]