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BPC-157 is a synthetic 15-amino acid peptide: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val

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Local release of 177 Lu provided synovial radiotherapy, while the CG matrix attenuated synovitis by promoting macrophage polarization from M1 to M2, lowering proinflammatory cytokines, decreasing iNOS, increasing CD206, and scavenging reactive oxygen species